Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 2 Teaspoons (10 ml)
Serving Per Container: 12
Amount Per Serving
%DV
Calories
25
Total Carbohydrate
7 g
3%†
Total Sugars
7 g
**
Includes 3.1 g Added Sugars
6.2%
Vitamin C (ascorbic acid)
110 mg
122%
Zinc (as zinc gluconate)
2.6 mg
24%
Black Elderberry Extract
3.8 g
**
Top Medical Research Studies
9
We evaluated how vitamin C, also known as ascorbic acid, can help protect the liver during procedures that temporarily cut off blood flow—a process known as ischaemia followed by reperfusion. In this study, we used thirty-six male Wistar rats, split into control groups and experimental ones. Each group received the same total dose of vitamin C, administered at different times: either before the ischaemia, before the reperfusion, or both.
Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.
This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.
This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
Read More
9
This study investigated how L-ascorbic acid 6-palmitate (L-AP), a derivative of vitamin C, could affect liver injury during sepsis. We focused on understanding its potential to alleviate liver damage caused by an overactive immune response. Through a series of experiments, including the cecal ligation and puncture method in mice, we observed that L-AP significantly increased the survival rates of these animals.
We found that L-AP treatment also reduced liver inflammation, which was evidenced by improved liver tissue health, less liver cell death, and lower levels of liver enzymes in the blood. Interestingly, the effects of L-AP were similar to the results seen in mice that lacked the NLRP3 inflammasome, a key player in inflammation.
Moreover, L-AP appeared to dampen the hyper-inflammatory response characteristic of sepsis. In both the liver tissues and cultured macrophages, we noted a decrease in inflammatory markers linked to the NLRP3 inflammasome pathway. This included lower expression levels of specific inflammatory proteins and less macrophage activation, promoting a more anti-inflammatory response instead.
Overall, our findings reveal that L-AP may help protect the liver during severe bacterial infections by mitigating the harmful effects of macrophage activation and the resultant inflammation. While this study points toward the possible benefits of an ascorbic acid derivative in treating septic liver damage, further investigation is necessary to fully unravel its mechanisms and potential therapeutic applications.
We found that L-AP treatment also reduced liver inflammation, which was evidenced by improved liver tissue health, less liver cell death, and lower levels of liver enzymes in the blood. Interestingly, the effects of L-AP were similar to the results seen in mice that lacked the NLRP3 inflammasome, a key player in inflammation.
Moreover, L-AP appeared to dampen the hyper-inflammatory response characteristic of sepsis. In both the liver tissues and cultured macrophages, we noted a decrease in inflammatory markers linked to the NLRP3 inflammasome pathway. This included lower expression levels of specific inflammatory proteins and less macrophage activation, promoting a more anti-inflammatory response instead.
Overall, our findings reveal that L-AP may help protect the liver during severe bacterial infections by mitigating the harmful effects of macrophage activation and the resultant inflammation. While this study points toward the possible benefits of an ascorbic acid derivative in treating septic liver damage, further investigation is necessary to fully unravel its mechanisms and potential therapeutic applications.
Read More
9
We focused on the connection between zinc and liver health, particularly how it may influence conditions like non-alcoholic fatty liver disease (NAFLD) and metabolic issues, including type II diabetes (T2D). Our analysis of data from a large genetics cohort revealed a significant finding: rare genetic variants that reduce the function of the zinc transporter SLC39A5 were linked to better metabolic profiles and lower T2D risk.
To delve deeper into these results, we used both laboratory and animal models. We developed mice that completely lacked SLC39A5 and observed promising outcomes. These mice showcased improved liver function and lower blood sugar levels after being subjected to obesity challenges, whether congenital or diet-induced.
Notably, this improvement seemed to be associated with increased levels of zinc in the liver, which activated key signaling pathways involved in metabolism, such as AMPK and AKT. Furthermore, these mice exhibited less liver inflammation and fibrosis in models of diet-induced non-alcoholic steatohepatitis (NASH).
Together, these findings position SLC39A5 as a potentially valuable target for treating liver-related metabolic disorders, emphasizing zinc's crucial role in managing liver health and blood sugar regulation.
To delve deeper into these results, we used both laboratory and animal models. We developed mice that completely lacked SLC39A5 and observed promising outcomes. These mice showcased improved liver function and lower blood sugar levels after being subjected to obesity challenges, whether congenital or diet-induced.
Notably, this improvement seemed to be associated with increased levels of zinc in the liver, which activated key signaling pathways involved in metabolism, such as AMPK and AKT. Furthermore, these mice exhibited less liver inflammation and fibrosis in models of diet-induced non-alcoholic steatohepatitis (NASH).
Together, these findings position SLC39A5 as a potentially valuable target for treating liver-related metabolic disorders, emphasizing zinc's crucial role in managing liver health and blood sugar regulation.
Read More
Most Useful Reviews
9
Antioxidant properties highlighted
It is one of the premier tools in combating viruses, containing a record number of antioxidants and significantly outperforming other plants against the influenza virus. Black elderberry exhibits diaphoretic, bactericidal, and anti-inflammatory properties. Its effectiveness peaks on the first day, so it’s essential to use it upon the first symptoms of illness, enabling a swift recovery from ARVI and flu.
Read More
9
Boosts immunity
Great. This is a wonderful booster for immunity. As soon as someone in the family feels the first signs of a cold, I take this syrup. The cold either recedes or passes quite easily and quickly.
Read More
7.5
Recovery aid confirmed
I bought this elderberry syrup for my seven-year-old child. Initially, I thought there was no impact from the syrup, but when the child fell ill again and I chose not to provide the syrup, I realised its benefit! While it won’t miraculously eliminate all symptoms instantly, it genuinely aids the body in fighting the illness, making recovery smoother. Unfortunately, the price has doubled recently!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.6
- All Researches
9.5
Vitamin C enhances liver cancer treatment
We observed an intriguing case involving a 68-year-old male patient diagnosed with unresectable hepatocellular carcinoma (HCC). This case focused on the potential benefits of incorporating high-dose intravenous vitamin C into the treatment regimen alongside atezolizumab and bevacizumab.
Initially, the patient underwent the combination therapy, but while the imaging showed stable disease, there was only a modest decline in alpha-fetoprotein (AFP) levels. Unfortunately, the patient's condition further declined. In response, a dose of 30 grams of intravenous vitamin C was added to the treatment plan.
Remarkably, this adjustment led to a swift and noteworthy reduction in AFP levels, normalization of liver function tests, and substantial improvement in overall symptoms. Four months later, imaging indicated significant tumor shrinkage and necrosis.
As of 30 months post-diagnosis, the patient benefits from the combined regimen, showing normal liver function and a dramatically reduced AFP level, all while maintaining an active lifestyle. This case demonstrates the potential synergistic effects of high-dose vitamin C in treating unresectable HCC alongside standard therapies, warranting further investigation into such combination approaches.
Initially, the patient underwent the combination therapy, but while the imaging showed stable disease, there was only a modest decline in alpha-fetoprotein (AFP) levels. Unfortunately, the patient's condition further declined. In response, a dose of 30 grams of intravenous vitamin C was added to the treatment plan.
Remarkably, this adjustment led to a swift and noteworthy reduction in AFP levels, normalization of liver function tests, and substantial improvement in overall symptoms. Four months later, imaging indicated significant tumor shrinkage and necrosis.
As of 30 months post-diagnosis, the patient benefits from the combined regimen, showing normal liver function and a dramatically reduced AFP level, all while maintaining an active lifestyle. This case demonstrates the potential synergistic effects of high-dose vitamin C in treating unresectable HCC alongside standard therapies, warranting further investigation into such combination approaches.
Read More
9
We evaluated how vitamin C, also known as ascorbic acid, can help protect the liver during procedures that temporarily cut off blood flow—a process known as ischaemia followed by reperfusion. In this study, we used thirty-six male Wistar rats, split into control groups and experimental ones. Each group received the same total dose of vitamin C, administered at different times: either before the ischaemia, before the reperfusion, or both.
Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.
This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.
This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
Read More
9
This study investigated how L-ascorbic acid 6-palmitate (L-AP), a derivative of vitamin C, could affect liver injury during sepsis. We focused on understanding its potential to alleviate liver damage caused by an overactive immune response. Through a series of experiments, including the cecal ligation and puncture method in mice, we observed that L-AP significantly increased the survival rates of these animals.
We found that L-AP treatment also reduced liver inflammation, which was evidenced by improved liver tissue health, less liver cell death, and lower levels of liver enzymes in the blood. Interestingly, the effects of L-AP were similar to the results seen in mice that lacked the NLRP3 inflammasome, a key player in inflammation.
Moreover, L-AP appeared to dampen the hyper-inflammatory response characteristic of sepsis. In both the liver tissues and cultured macrophages, we noted a decrease in inflammatory markers linked to the NLRP3 inflammasome pathway. This included lower expression levels of specific inflammatory proteins and less macrophage activation, promoting a more anti-inflammatory response instead.
Overall, our findings reveal that L-AP may help protect the liver during severe bacterial infections by mitigating the harmful effects of macrophage activation and the resultant inflammation. While this study points toward the possible benefits of an ascorbic acid derivative in treating septic liver damage, further investigation is necessary to fully unravel its mechanisms and potential therapeutic applications.
We found that L-AP treatment also reduced liver inflammation, which was evidenced by improved liver tissue health, less liver cell death, and lower levels of liver enzymes in the blood. Interestingly, the effects of L-AP were similar to the results seen in mice that lacked the NLRP3 inflammasome, a key player in inflammation.
Moreover, L-AP appeared to dampen the hyper-inflammatory response characteristic of sepsis. In both the liver tissues and cultured macrophages, we noted a decrease in inflammatory markers linked to the NLRP3 inflammasome pathway. This included lower expression levels of specific inflammatory proteins and less macrophage activation, promoting a more anti-inflammatory response instead.
Overall, our findings reveal that L-AP may help protect the liver during severe bacterial infections by mitigating the harmful effects of macrophage activation and the resultant inflammation. While this study points toward the possible benefits of an ascorbic acid derivative in treating septic liver damage, further investigation is necessary to fully unravel its mechanisms and potential therapeutic applications.
Read More
9
We focused on the connection between zinc and liver health, particularly how it may influence conditions like non-alcoholic fatty liver disease (NAFLD) and metabolic issues, including type II diabetes (T2D). Our analysis of data from a large genetics cohort revealed a significant finding: rare genetic variants that reduce the function of the zinc transporter SLC39A5 were linked to better metabolic profiles and lower T2D risk.
To delve deeper into these results, we used both laboratory and animal models. We developed mice that completely lacked SLC39A5 and observed promising outcomes. These mice showcased improved liver function and lower blood sugar levels after being subjected to obesity challenges, whether congenital or diet-induced.
Notably, this improvement seemed to be associated with increased levels of zinc in the liver, which activated key signaling pathways involved in metabolism, such as AMPK and AKT. Furthermore, these mice exhibited less liver inflammation and fibrosis in models of diet-induced non-alcoholic steatohepatitis (NASH).
Together, these findings position SLC39A5 as a potentially valuable target for treating liver-related metabolic disorders, emphasizing zinc's crucial role in managing liver health and blood sugar regulation.
To delve deeper into these results, we used both laboratory and animal models. We developed mice that completely lacked SLC39A5 and observed promising outcomes. These mice showcased improved liver function and lower blood sugar levels after being subjected to obesity challenges, whether congenital or diet-induced.
Notably, this improvement seemed to be associated with increased levels of zinc in the liver, which activated key signaling pathways involved in metabolism, such as AMPK and AKT. Furthermore, these mice exhibited less liver inflammation and fibrosis in models of diet-induced non-alcoholic steatohepatitis (NASH).
Together, these findings position SLC39A5 as a potentially valuable target for treating liver-related metabolic disorders, emphasizing zinc's crucial role in managing liver health and blood sugar regulation.
Read More
9
We explored how zinc supplementation could help manage cholestatic liver disease, a condition that currently lacks effective treatment options. Our study involved both mice and human participants, revealing interesting changes in gut microbiome dynamics when zinc was introduced. Specifically, we noted that zinc boosts levels of a beneficial bacterium called Blautia producta, which in turn helps produce p-coumaric acid.
The fascinating part is that higher p-coumaric acid levels were linked to reduced liver injury in patients with cholestatic liver disease. In experiments with mice, we found that the protective effects of zinc were partly due to the ability of p-coumaric acid to limit harmful reactive oxygen species in liver cells. This suggests that p-coumaric acid directly supports liver health by preventing cell death and damage.
However, the benefits of zinc were less pronounced when we manipulated the production of p-coumaric acid. This implies that the relationship between zinc, gut bacteria, and liver health is quite intricate. Overall, our findings suggest that zinc may provide valuable support for individuals suffering from cholestatic liver disease, primarily through its influence on the gut microbiome and subsequent metabolic processes.
The fascinating part is that higher p-coumaric acid levels were linked to reduced liver injury in patients with cholestatic liver disease. In experiments with mice, we found that the protective effects of zinc were partly due to the ability of p-coumaric acid to limit harmful reactive oxygen species in liver cells. This suggests that p-coumaric acid directly supports liver health by preventing cell death and damage.
However, the benefits of zinc were less pronounced when we manipulated the production of p-coumaric acid. This implies that the relationship between zinc, gut bacteria, and liver health is quite intricate. Overall, our findings suggest that zinc may provide valuable support for individuals suffering from cholestatic liver disease, primarily through its influence on the gut microbiome and subsequent metabolic processes.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Antioxidant properties highlighted
It is one of the premier tools in combating viruses, containing a record number of antioxidants and significantly outperforming other plants against the influenza virus. Black elderberry exhibits diaphoretic, bactericidal, and anti-inflammatory properties. Its effectiveness peaks on the first day, so it’s essential to use it upon the first symptoms of illness, enabling a swift recovery from ARVI and flu.
Read More
9
Boosts immunity
Great. This is a wonderful booster for immunity. As soon as someone in the family feels the first signs of a cold, I take this syrup. The cold either recedes or passes quite easily and quickly.
Read More
7.5
Recovery aid confirmed
I bought this elderberry syrup for my seven-year-old child. Initially, I thought there was no impact from the syrup, but when the child fell ill again and I chose not to provide the syrup, I realised its benefit! While it won’t miraculously eliminate all symptoms instantly, it genuinely aids the body in fighting the illness, making recovery smoother. Unfortunately, the price has doubled recently!
Read More
7.5
Better health
Good quality for supporting immunity. It has a pleasant taste, and my child has become less sick. The course of illnesses has improved significantly. The benefits of taking elderberry are well established!
Read More
Frequently Asked Questions
9
Antioxidant properties highlighted
It is one of the premier tools in combating viruses, containing a record number of antioxidants and significantly outperforming other plants against the influenza virus. Black elderberry exhibits diaphoretic, bactericidal, and anti-inflammatory properties. Its effectiveness peaks on the first day, so it’s essential to use it upon the first symptoms of illness, enabling a swift recovery from ARVI and flu.
9
Boosts immunity
Great. This is a wonderful booster for immunity. As soon as someone in the family feels the first signs of a cold, I take this syrup. The cold either recedes or passes quite easily and quickly.
7.5
Recovery aid confirmed
I bought this elderberry syrup for my seven-year-old child. Initially, I thought there was no impact from the syrup, but when the child fell ill again and I chose not to provide the syrup, I realised its benefit! While it won’t miraculously eliminate all symptoms instantly, it genuinely aids the body in fighting the illness, making recovery smoother. Unfortunately, the price has doubled recently!
7.5
Better health
Good quality for supporting immunity. It has a pleasant taste, and my child has become less sick. The course of illnesses has improved significantly. The benefits of taking elderberry are well established!
7
We examined how a poor vitamin C status might influence the progression of a specific type of liver disease known as metabolic dysfunction-associated steatohepatitis (MASH) in juvenile guinea pigs. This model is important because children and teenagers often experience unique forms of MASH, yet there is a lack of studies and animal models to fully understand it.
In our study, we conditioned sixty-two young guinea pigs with a high-fat diet for 16 weeks, simulating a scenario that can occur in children. We observed that these young guinea pigs demonstrated liver damage typical of pediatric MASH, including inflammation and fibrosis, but their steatosis levels were noticeably lower compared to adults.
Remarkably, guinea pigs with vitamin C deprivation not only had reduced body weight but also showed elevated levels of inflammatory gene expressions in their livers. This suggests that a deficiency in vitamin C could play a vital role in altering gene expressions linked to liver disease.
While our results indicate a connection between poor vitamin C levels and the progression of pediatric MASH, the study’s limitations prevent us from making direct conclusions about the effectiveness of vitamin C as a standalone treatment. It remains critical to explore the combined effects of nutritional deficiencies, like low vitamin C, on the advancement of liver disease.
In our study, we conditioned sixty-two young guinea pigs with a high-fat diet for 16 weeks, simulating a scenario that can occur in children. We observed that these young guinea pigs demonstrated liver damage typical of pediatric MASH, including inflammation and fibrosis, but their steatosis levels were noticeably lower compared to adults.
Remarkably, guinea pigs with vitamin C deprivation not only had reduced body weight but also showed elevated levels of inflammatory gene expressions in their livers. This suggests that a deficiency in vitamin C could play a vital role in altering gene expressions linked to liver disease.
While our results indicate a connection between poor vitamin C levels and the progression of pediatric MASH, the study’s limitations prevent us from making direct conclusions about the effectiveness of vitamin C as a standalone treatment. It remains critical to explore the combined effects of nutritional deficiencies, like low vitamin C, on the advancement of liver disease.
8
In our exploration of the connection between dietary antioxidants and liver health, we analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2020. A key focus was on the composite dietary antioxidant index (CDAI), which includes essential nutrients like vitamin C.
We found that higher CDAI scores were associated with a lower likelihood of developing metabolic dysfunction-associated fatty liver disease (MAFLD). For those in the highest quartile of CDAI, there was a noted 27% reduction in the chance of having MAFLD compared to those in the lowest quartile.
Importantly, changes in vitamin C intake were found to be linked to MAFLD, suggesting that this vitamin may play a role in liver health. Our subgroup analysis particularly highlighted those engaging in moderate-intensity physical activity, reinforcing the idea that a diet rich in antioxidants, including vitamin C, could be beneficial for liver function.
This study opens the door to exploring dietary interventions that potentially reduce the incidence of MAFLD, highlighting the importance of getting enough vitamin C in our diets.
We found that higher CDAI scores were associated with a lower likelihood of developing metabolic dysfunction-associated fatty liver disease (MAFLD). For those in the highest quartile of CDAI, there was a noted 27% reduction in the chance of having MAFLD compared to those in the lowest quartile.
Importantly, changes in vitamin C intake were found to be linked to MAFLD, suggesting that this vitamin may play a role in liver health. Our subgroup analysis particularly highlighted those engaging in moderate-intensity physical activity, reinforcing the idea that a diet rich in antioxidants, including vitamin C, could be beneficial for liver function.
This study opens the door to exploring dietary interventions that potentially reduce the incidence of MAFLD, highlighting the importance of getting enough vitamin C in our diets.
8
We investigated whether vitamin C could help protect the liver from damage caused by electron beam therapy, a treatment often used for cancers in the abdomen. Our study involved male Wistar rats, which were divided into four groups: one received electron irradiation, one was pre-treated with vitamin C, another received vitamin C alone, and the last group served as a control.
Through detailed analyses, we looked at various markers of liver health, such as liver enzymes and inflammatory cytokines. We also examined the liver tissues of the rats over 90 days to assess any changes. What we found was quite revealing; the group exposed to radiation showed significant liver damage, increased liver enzymes, inflammation, and signs of oxidative stress.
Interestingly, those rats pre-treated with vitamin C experienced milder liver damage and lower levels of oxidative stress and inflammation. This suggests that vitamin C may help maintain a better balance between liver cell growth and cell death, which is crucial after radiation exposure. Overall, our results indicate that vitamin C has potential as a protective agent against radiation-induced liver injury.
Still, while our findings are promising, further research is needed to fully understand the long-term benefits of vitamin C in this context.
Through detailed analyses, we looked at various markers of liver health, such as liver enzymes and inflammatory cytokines. We also examined the liver tissues of the rats over 90 days to assess any changes. What we found was quite revealing; the group exposed to radiation showed significant liver damage, increased liver enzymes, inflammation, and signs of oxidative stress.
Interestingly, those rats pre-treated with vitamin C experienced milder liver damage and lower levels of oxidative stress and inflammation. This suggests that vitamin C may help maintain a better balance between liver cell growth and cell death, which is crucial after radiation exposure. Overall, our results indicate that vitamin C has potential as a protective agent against radiation-induced liver injury.
Still, while our findings are promising, further research is needed to fully understand the long-term benefits of vitamin C in this context.
7
We investigated the effects of vitamin C on liver health, particularly how it might help mitigate liver damage caused by methotrexate, a common chemotherapy drug. In our study, we observed Swiss albino mice divided into five groups, with one group receiving vitamin C along with omega-3 fatty acids.
The results were promising; pretreatment with both vitamin C and omega-3 showed a noteworthy ability to lessen liver damage. After assessing the levels of certain enzymes and antioxidants in the blood, we found that the combination treatment significantly reduced oxidative stress markers compared to those that received methotrexate alone.
While each treatment alone played a role, it was the combination that truly stood out. Our findings suggest that vitamin C, especially when paired with omega-3, could offer protective benefits against liver toxicity induced by medications like methotrexate. This adds a dimension to the conversation on managing liver health during such treatments.
The results were promising; pretreatment with both vitamin C and omega-3 showed a noteworthy ability to lessen liver damage. After assessing the levels of certain enzymes and antioxidants in the blood, we found that the combination treatment significantly reduced oxidative stress markers compared to those that received methotrexate alone.
While each treatment alone played a role, it was the combination that truly stood out. Our findings suggest that vitamin C, especially when paired with omega-3, could offer protective benefits against liver toxicity induced by medications like methotrexate. This adds a dimension to the conversation on managing liver health during such treatments.
7
We explored the connection between vitamin C and nonalcoholic fatty liver disease (NAFLD), focusing on how dietary potassium may affect this relationship. Using data from a large-scale study with over 9,000 participants, we employed advanced statistical methods to analyze vitamin C's potential benefits in reducing NAFLD and advanced hepatic fibrosis (AHF).
Our findings revealed that vitamin C intake was associated with lower levels of NAFLD and AHF. Interestingly, the degree of potassium intake appeared to play a critical role in this relationship. In groups with low, moderate, and high potassium consumption, the impact of vitamin C on NAFLD varied. This suggests that potassium intake could alter how effectively vitamin C protects liver health.
Ultimately, we observed that potassium and vitamin C together enhance their protective effects against liver disease, underscoring the importance of considering dietary factors when addressing liver health. These insights could guide future clinical practices and dietary recommendations for individuals concerned about liver disease.
Our findings revealed that vitamin C intake was associated with lower levels of NAFLD and AHF. Interestingly, the degree of potassium intake appeared to play a critical role in this relationship. In groups with low, moderate, and high potassium consumption, the impact of vitamin C on NAFLD varied. This suggests that potassium intake could alter how effectively vitamin C protects liver health.
Ultimately, we observed that potassium and vitamin C together enhance their protective effects against liver disease, underscoring the importance of considering dietary factors when addressing liver health. These insights could guide future clinical practices and dietary recommendations for individuals concerned about liver disease.
8
We explored the connection between dietary potassium intake, vitamin C, and their effects on liver health, specifically focusing on conditions like nonalcoholic fatty liver disease (NAFLD) and advanced hepatic fibrosis (AHF). The analysis was based on data from a large-scale study involving 9,443 participants over a period of 11 years.
Our findings revealed that a higher intake of dietary potassium was associated with a significant decrease in the likelihood of developing both NAFLD and AHF. For instance, individuals in the highest potassium intake group showed a 31% reduction in the odds of NAFLD and a 42% reduction in the odds of AHF compared to those with the lowest intake.
We also observed an intriguing interaction where higher levels of vitamin C in the diet seemed to strengthen the protective effects of potassium against liver disease. However, while the results highlight a positive relationship between potassium intake and liver health, the direct impact of vitamin C alone has not been thoroughly defined.
Overall, these findings suggest that maintaining a diet rich in potassium—especially when combined with vitamin C—might offer protective benefits for liver health, although further research is needed to fully understand these relationships.
Our findings revealed that a higher intake of dietary potassium was associated with a significant decrease in the likelihood of developing both NAFLD and AHF. For instance, individuals in the highest potassium intake group showed a 31% reduction in the odds of NAFLD and a 42% reduction in the odds of AHF compared to those with the lowest intake.
We also observed an intriguing interaction where higher levels of vitamin C in the diet seemed to strengthen the protective effects of potassium against liver disease. However, while the results highlight a positive relationship between potassium intake and liver health, the direct impact of vitamin C alone has not been thoroughly defined.
Overall, these findings suggest that maintaining a diet rich in potassium—especially when combined with vitamin C—might offer protective benefits for liver health, although further research is needed to fully understand these relationships.
References
- Pedersen K, Poojari A, Colberg SF, Mechernsee SM, Iversen JF, et al. A Guinea Pig Model of Pediatric Metabolic Dysfunction-Associated Steatohepatitis: Poor Vitamin C Status May Advance Disease. Nutrients. 2025;17. doi:10.3390/nu17020291
- Dong JX, Jiang LL, Liu YP, Zheng AX. Association between composite dietary antioxidant index and metabolic dysfunction-associated fatty liver disease: a cross-sectional study from NHANES. BMC Gastroenterol. 2024;24:465. doi:10.1186/s12876-024-03556-6
- Demyashkin G, Parshenkov M, Koryakin S, Skovorodko P, Shchekin V, et al. Targeting Oxidative Stress: The Potential of Vitamin C in Protecting against Liver Damage after Electron Beam Therapy. Biomedicines. 2024;12. doi:10.3390/biomedicines12102195
- Mohammed D, Al-Gareeb AM. Evaluation the effects of Omega-3 and vitamin C alone or in combination on Methotrexate-Induced hepatotoxicity (in mice). J Pak Med Assoc. 2024;74:S414. doi:10.47391/JPMA-BAGH-16-94
- Kian W, Remilah AA, Shatat C, Spector M, Roisman LC, et al. Case report: The efficacy of adding high doses of intravenous vitamin C to the combination therapy of atezolizumab and bevacizumab in unresectable HCC. Front Med (Lausanne). 2024;11:1461127. doi:10.3389/fmed.2024.1461127
- Thadeus MS, Susantiningsih T, Muktamiroh H, Fauziah C, Citrawati M, et al. fruit extract as a potential antioxidant against liver injury by 2-Nitropropane induction in obese male mice model: pre-clinical study. F1000Res. 2023;12:300. doi:10.12688/f1000research.121695.2
- Ximenes JLS, Rocha-Filho JA, Galvão FHF, Lanchotte C, Kubrusly MS, et al. The Effect of Ascorbic Acid on Hepatic Ischaemia-Reperfusion Injury in Wistar Rats: An Experimental Study. Int J Mol Sci. 2024;25. doi:10.3390/ijms25168833
- Chen HK, Lan QW, Li YJ, Xin Q, Luo RQ, et al. Association between Dietary Potassium Intake and Nonalcoholic Fatty Liver Disease and Advanced Hepatic Fibrosis in U.S. Adults. Int J Endocrinol. 2024;2024:5588104. doi:10.1155/2024/5588104
- Jaffey JA, Chamberlin T, Hu J. Acute manganese toxicosis related to joint health supplement ingestion in two dogs. Top Companion Anim Med. 2024;61:100877. doi:10.1016/j.tcam.2024.100877
- Liu XH, Chen HK, Luo J, He XP, Zhang WL, et al. Potassium affects the association between dietary intake of vitamin C and NAFLD among adults in the United States. PLoS One. 2024;19:e0295986. doi:10.1371/journal.pone.0295986
- Liu L, Lin L, Wang Y, Yan X, Li R, et al. L-AP Alleviates Liver Injury in Septic Mice by Inhibiting Macrophage Activation via Suppressing NF-κB and NLRP3 Inflammasome/Caspase-1 Signal Pathways. J Agric Food Chem. 2024;72:8460. doi:10.1021/acs.jafc.3c02781
- Semeya AA, Elgamal R, Othman AAA. Correlation of Serum Zinc Levels with Hepatic Encephalopathy Severity in Patients with Decompensated Liver Cirrhosis: A Prospective Observational Study from Egypt. Biol Trace Elem Res. 2025. doi:10.1007/s12011-025-04544-x
- Afşar E, Kantar D. How does zinc chelation affect liver sphingolipid metabolism in an Alzheimer's-like model?. J Trace Elem Med Biol. 2025;87:127589. doi:10.1016/j.jtemb.2025.127589
- Amooyi L, Alizadeh L, Sarbakhsh P, Shojaei-Zarghani S, Gharekhani A. The Effects of Adding Probiotic, Alone and in Combination With Zinc, to Routine Treatment on Recurrence of Hepatic Encephalopathy, Quality of Life, and Sleep Quality in Patients With Cirrhosis: An Open-Label Randomized Controlled Trial. Food Sci Nutr. 2025;13:e4636. doi:10.1002/fsn3.4636
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